• Need for Controlling the Environment in Dry Eye Disease Clinical Studies

1.  Exposure to a controlled adverse environment impairs the ocular surface of subjects with minimally symptomatic dry eye. González-García MJ, González-Sáiz A, De la Fuente B, Morilla-Grasa A, Mayo-Iscar A, San José J, Feijó J, Stern ME, Calonge M.. Invest Ophthalmol Vis Sci 2007;48:4026-4032.

2.  Influence of climate on clinical diagnostic dry eye tests: pilot study. Tesón M, López-Miguel A, Neves H, Calonge M, González-García MJ, González-Méijome JM. Optom Vis Sci 2015;92:284-289.

  • Effect of Controlled (Normal or Adverse) Environment in Dry Eye Disease – Biomarkers

Controls, Sjögren- and non Sjögren-associated Dry Eye

3.  Influence of a controlled environment simulating an in flight airplane cabin on dry eye disease. Tesón M, Gonzalez MJ, Lopez-Miguel A, Enríquez de Salamanca A, Martín-Montañez V, Benito MJ, Mateo MJ, Stern M, Calonge M. Invest Ophthalmol Clin Sci 2013;54:2093-2099.

4.  Dry eye exacerbation in patients exposed to desiccating stress under controlled environmental conditions. López-Miguel A, Tesón M, Martín-Montañez V, Enríquez-de-Salamanca A, Stern ME, Calonge M, González-García MJ. Am J Ophthalmol 2014;157:788-798.

5.  Clinical and molecular inflammatory response in Sjögren syndrome-sssociated dry eye patients uner desiccating stress. Lopez-Miguel A, Tesón M, Martin-Montañez V, Enriquez-de-Salamanca A, Stern ME, Gonzalez-Garcia MJ, Calonge M. Am J Ophthalmol 2016;161:133-141.

6.  Response profiles to a controlled adverse desiccating environment based on clinical and tear molecule changes. Fernández I, López-Miguel A, Enríquez-de-Salamanca A, Tesón M, Stern ME, González-García MJ, Calonge M. Ocul Surf. 2019;17:502-515.

Graft versus Host Disease (GvHD)-related Dry Eye

7.  Gene expression-based predictive models of graft versus host disease-associated dry eye. Cocho L, Fernandez I, Calonge M, Martinez V, González-García MJ, Caballero D, López-Corral L, García-Vazquez C, Vázquez L, Stern ME. Invest Ophthalmol Vis Sci 2015;56:4570-4581.

8.  Biomarkers in ocular chronic versus host disease: tear cytokine- and chemokine-based predictive model. Cocho L, Fernández I, Calonge M, Martínez V, González-García MJ, Caballero D, López-Corral L, García-Vázquez C. Vázquez L, Stern ME, Enríquez-de-Salamanca A. Invest Ophthalmol Vis Sci 2016;57:746-758.

9.  Prehematopoietic stem cell transplantation tear cytokines as potential susceptibility biomarkers for ocular chronic graft-versus-host disease. Cocho L, Fernández I, Calonge M, Sainz de la Maza M, Rovira M, Stern ME, Garcia-Vazquez C, Enríquez-de-Salamanca A. Invest Ophthalmol Vis Sci 2017;58:4836-4846.

  • Proof-of-concept therapeutic clinical trial in CELab – Biomarkers

10.  Topical fluorometholone protects the ocular surface of dry eye patients from desiccating stress: a Randomized Controlled Clinical Trial. Pinto-Fraga J, Lopez-Miguel A, Gonzalez-Garcia MJ, Fernandez I, Lopez-de-la-Rosa A, Enriquez-de-Salamanca A, Stern ME, Calonge M. Ophthalmology 2016;123:141-153.

11.  Topical fluorometholone treatment and desiccating stress change inflammatory protein expression in tears. Nättinen J, Jylhä A, Aapola U, Enríquez-de-Salamanca A, Pinto-Fraga J, López-Miguel A, González-García MJ, Stern ME, Calonge M, Zhou L, Nykter M, Uusitalo H, Beuerman R. Ocul Surf. 2017 2018;16:84-92.

12.  Severity, therapeutic, and activity tear biomarkers in dry eye disease: analysis from a phase III clinical trial. Pinto-Fraga J, Enríquez-de-Salamanca A, Calonge M, González-García MJ, López-Miguel A, López-de la Rosa A, García-Vázquez C, Calder V, Stern ME, Fernández I. Ocul Surf 2018;16:368-376.

13. Effect of a single vectored thermal pulsation treatment of Meibomian gland dysfunction patients under controlled environmental conditions. Novo-Diez A, López-Miguel A, Fernández I, Blanco-Vázquez M, Valencia-Sandonís C, Enríquez-de-Salamanca A, González-García MJ, Calonge M. Sci Rep. 2022;12:16761.

  • Effect of Controlled (Normal or Adverse) Environment in Contact Lens Discomfort – Biomarkers

14.  Influence of environmental factors in the in vitro dehydration of hydrogel and silicone hydrogel contact lenses. Martín-Montañez V, López-Miguel A, Arroyo C, Mateo ME, González-Méijome JM, Calonge M, González-García MJ. J Biomed Mater Res B Appl Biomater. 2014;102: 764-771.

15.  Effect of environmental conditions on the concentration of tear inflammatory mediators during contact lens wear. Martín-Montañez V, Enríquez-de-Salamanca A, López-de la Rosa A, López-Miguel A, Fernández I, Calonge M, González-Méijome JM, González-García MJ. Cornea, 2016;35:1192-1198.

16.  Ocular response to environmental variations in contact lens wearers. López-de la Rosa A, Martín-Montañez V, López-Miguel A, Fernández I, Calonge M, González-Méijome JM, González-García MJ. Ophthalmic Physiol Opt. 2017;37:60-70.

17.  Inflammatory status predicts contact lens discomfort under adverse environmental conditions. Fernández I, López-Miguel A, Martín-Montañez V, Enríquez-de-Salamanca A, Calonge M, González-Méijome JM, González-García MJ. Ocul Surf. 2020;18:829-840.

  • Reviews

18.  Effects of the External Environment on Dry Eye Disease. Calonge M, Pinto-Fraga J, González-García MJ, Enríquez-de-Salamanca A, López-de la Rosa A, Fernández I, López-Miguel A. Int Ophthalmol Clin 2017;57:23-40.

19.  Controlled Adverse Environment Chambers in Dry Eye Research. Calonge M, Labetoulle M, Messmer EM, Shah S, Akova YA, Boboridis KG, Merayo-Lloves J, Aragona P, Benítez-Del-Castillo J, Geerling G, Rolando M, Baudouin C. Curr Eye Res. 2018;43:445-450.